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Oral ketoconazole has been used clinically as a steroidogenesis inhibitor in men, women, and children at dosages of 200 to 1,200 mg/day. [ 47 ] [ 48 ] [ 49 ] Numerous small studies have investigated the effects of oral ketoconazole on hormone levels in humans. [ 50 ]
The earlier Young's rule [1] for calculating the correct dose of medicine for a child is similar: it states that the child dosage is equal to the adult dosage multiplied by the child's age in years, divided by the sum of 12 plus the child's age. Young's rule was named after Thomas Young (1773–1829), an English polymath, physician and ...
In July 2013, the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) advised that oral medicines containing Ketoconazole should be suspended due to the high risk of hepatotoxicity outweighing its benefits. The advice does not affect topical ketoconazole products, and the oral use of the drug for Cushing's syndrome.
The study did not show measurable systemic levels or hematopoietic side effects, suggesting potential for use in humans. [93] Low energy radiofrequency irradiation induces IGF-1 in cultured human dermal papilla cells. [94] Adenosine stimulates dermal papillae in vitro to induce IGF-1, along with fibroblast growth factors FGF7, FGF-2 and VEGF.
One formula for cat years is based on a cat reaching maturity in approximately 1 year, which could be seen as 16 in human terms, then adding about 4 years for every year the cat ages. A 5-year-old cat would then be (5 − 1) × 4 + 16 = 32 "cat years" (i.e. human-equivalent years), and a 10-year-old cat (10 − 1) × 4 + 16 = 52 in human terms. [7]
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Subsequently, the National Academy of Sciences (NAS) reviewed the health implications of perchlorate, and in 2005 proposed a much higher alternative reference dose of 0.0007 mg/kg/day based primarily on a 2002 study by Greer et al. [6] During that study, 37 adult human subjects were split into four exposure groups exposed to 0.007 (7 subjects ...
Research on animal reproduction has indicated that there is a trace of teratogenicity when doses are reduced by 10 times the human recommended dose. [54] There is no sufficient information on human pregnancy at this moment. Use is only recommended when the potential benefits outweigh the potential risks for the pregnant mother and the fetus. [54]