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It was also banned in India. [9] As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine.
Compound analgesics were banned in Australia in 1979 due to analgesic nephropathy. [8] Phenacetin, a pain-relieving and fever-reducing drug, was banned by the FDA in the US in 1983, due to its adverse effects, which include kidney damage (as shown by Dr. Priscilla Kincaid-Smith) [9] [10] and cancer. [11]
Saridon was first launched by Roche in 1933, initially containing pyrithyldione and phenacetin, widely used remedies for fever and pain. It often contained aspirin, phenacetin and caffeine, but was reformulated in 1981, replacing the original ingredient phenacetin with paracetamol, before phenacetin was banned by the US FDA in 1983. It was ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic ...
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With further reports of the increased risk of kidney injury with prolonged and excessive phenacetin use, however, phenacetin was banned in several countries between the 1960s and 1980s. [20] As the use of phenacetin declined, so too did the prevalence of analgesic nephropathy as a cause of end-stage kidney disease.