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The albino laboratory mouse is an iconic model organism for scientific research in a variety of fields An SCID Intermediate coat colour Kept as a pet. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets.
In the U.S., the numbers of rats and mice used are not reported, but estimates range from around 11 million [3] to approximately 100 million. [4] In 2000, the Federal Research Division, Library of Congress, published the results of an analysis of its Rats/Mice/and Birds Database: Researchers, Breeders, Transporters, and Exhibitors.
The Research Institutes for Experimental Medicine are a research facility in Berlin, Germany. [1] This building is commonly known as Mouse Bunker , or Mäusebunker in German . Until 2003, its official name was Central Animal Laboratories of the Free University of Berlin .
This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments, and commercial facilities that provide animal-testing services to the industry. [1]
Harlan Laboratories says it is "dedicated to the humane care and use of research animals". [7] The IACUC and the company's veterinary staff manage policies and procedures to ensure that all animal use is performed in accordance with government and industry standards. [8]
This is, in part, because different stakeholders (e.g. animal experimenters, institutional figures, policy makers, activists and the public) may interpret the Three Rs differently. [ 19 ] [ 20 ] The 3Rs principles do not address some issues, such as the ethics of using animals in research and focus instead on improving the humane use of animals ...
Genetically modified mice have been the most common mammals used in biomedical research, as they are cheap and easy to manipulate. Examples include humanized mice created by xenotransplantation of human gene products, so as to be utilized as murine human-animal hybrids for gaining relevant insights in the in vivo context for understanding of ...
Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.