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Indolent lymphoma, also known as low-grade lymphoma, is a group of slow-growing non-Hodgkin lymphomas (NHLs). [3] Because they spread slowly, they tend to have fewer signs and symptoms when first diagnosed and may not require immediate treatment. Symptoms can include swollen but painless lymph nodes, unexplained fever, and unintended weight ...
With an indolent lymphoma, such as follicular lymphoma, watchful waiting is often the initial course of action, because monitoring is less risky and less harmful than early treatment. [50] If a low-grade lymphoma becomes symptomatic, radiotherapy or chemotherapy are the treatments of choice.
Radiotherapy is the most effective treatment for local disease either as the sole treatment for low-grade lymphoma or in combination with chemotherapy for intermediate- and high-grade lymphoma. [8] [9] Radiotherapy dose in range of 30-45 Gy administered in fractions are advised in treating the local orbital lymphomas. [10]
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. [1] Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. [1] Other symptoms may include bone pain, chest pain, or itchiness. [1]
Prognosis and treatment depends on the specific type of lymphoma as well as the stage and grade. Treatment includes radiation and chemotherapy. Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-recurrence.
The lesions are classified as low grade (i.e. Lugano classification Grades 1 or 2) in 95-100% of cases. Immunochemical analyses indicate that the latter cells express CD20 , CD10 , BCL6 , [ 2 ] and CD79A [ 6 ] and have a very low proliferation rate as defined by the intensity of their expression of Ki-67 . [ 6 ]
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