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Unlike many of the other injectable medications for weight loss and diabetes (e.g. Ozempic, Wegovy), Mounjaro is a dual glucose-dependent insulinotropic polypeptide, or GIP, and glucagon-like ...
GLP-1 can lead to reduced appetite and increased satiety (feeling full). GIP can have similar effects — it can increase lipolysis, which is the breakdown of fats for energy, among other things.
The difference here is that tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a GLP-1 receptor agonist. That means Mounjaro targets two receptors in the body ...
Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist. [14] Signaling studies reported that tirzepatide mimics the actions of natural GIP at the GIP receptor. [35]
But injectable type 2 diabetes medications — also known as GLP-1 and GIP injections — are changing the way we think about weight management. ... Mounjaro is also sometimes prescribed off-label ...
To break it down a bit more, Mounjaro activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, which are naturally occurring hormones found in ...
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