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Food products and household items commonly handled by humans can be toxic to dogs. The symptoms can range from simple irritation to digestion issues, behavioral changes, and even death. The categories of common items ingested by dogs include food products, human medication, household detergents, indoor and outdoor toxic plants, and rat poison. [1]
Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [4] [5] and in 2012, for cats. [6]
deracoxib – nonsteroidal anti-inflammatory drug (NSAID) dexamethasone – anti-inflammatory steroid; diazepam – benzodiazepine used to treat status epilepticus, also used as a preanaesthetic and a sedative; dichlorophene – fungicide, germicide, and antimicrobial agent, also used for the removal of parasites; diphenhydramine – histamine ...
Brodifacoum is a 4-hydroxycoumarin anticoagulant, with a similar mode of action to its historical predecessors dicoumarol and warfarin.However, due to very high potency and long duration of action (elimination half-life of 20 – 130 days), it is characterised as a "second-generation" or "superwarfarin" anticoagulant.
An antidote is a substance that can counteract a form of poisoning. [1] The term ultimately derives from the Greek term φάρμακον ἀντίδοτον (pharmakon antidoton), "(medicine) given as a remedy".
Samandarin is extremely toxic (LD 50 = 70 μg/kg in mice, [2] LD 50 = 700-900 μg/kg in dogs [3]) but little is known about its precise mechanism of action. Samandarin mainly affects the central nervous system, specifically neurons in the spinal cord. [1] No treatment or antidote is known for the poison. Although samandarin is thought to have ...