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An IRF of more than 0.23 but a subnormal or normal absolute reticulocyte count (with a corresponding reticulocyte production index of less than or equal to 2) is seen in for example acute infection, iron deficiency anemia, human immunodeficiency virus infection, sickle disease with crisis, pregnancy, and myelodysplastic syndrome. [2]
The simplest method for correcting the reticulocyte count, to obtain a more accurate daily production index, is to divide the corrected count by a factor of 2 (or multiply with ½) whenever polychromasia (the presence of immature marrow reticulocytes or "shift" cells) is observed on the smear or the immature fraction on the automated counter is ...
The reticulocyte production index (RPI) or corrected reticulocyte count (CRC) represents the true significance of the absolute reticulocyte count to provide some reflection of erythropoietic demand and supply. The immature reticulocyte fraction (IRF) goes a step further to cast more light on the same question. [citation needed]
The reticulocyte count is expressed as an absolute number [168] or as a percentage of red blood cells. [170] Some instruments measure the average amount of hemoglobin in each reticulocyte; a parameter that has been studied as an indicator of iron deficiency in people who have conditions that interfere with standard tests. [171]
Reticulocytosis is a laboratory finding in which the number of reticulocytes (immature red blood cells) in the bloodstream is elevated. Reticulocytes account for approximately 0.5% to 2.5% of the total red blood cells in healthy adults and 2% to 6% in infants, but in reticulocytosis, this percentage rises. [1]
If a low count of reticulocytes is found, it usually indicates bone marrow stress. If a high reticulocyte count is found, it is usually linked to hemolysis, but a Coombs test may be performed in this case to rule out immune-mediated hemolysis. [4] Polychromasia can also be seen in blood smears when there is a normal reticulocyte count.
A reticulocyte count that is high, normal or low will aid with the classification process. A high reticulocyte count signifies that bone marrow processes are normal. A low reticulocyte count would signify there is a problem at the level of the bone marrow, which produce the stem cells. Acute blood loss would result in a high reticulocyte count ...
Transient decrease in erythropoiesis resulting in low reticulocyte count with decrease in hemoglobin >/= 3 g/dL is considered to be aplastic crisis. [8] For the decrease in all cell lineages ( pancytopenia ), see aplastic anemia .