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Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei) [3] which is used as a template when it elongates telomeres. Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells.
Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. [5] [6] Telomerases are part of a distinct subgroup of RNA-dependent polymerases.
Telomerase RNA component, also known as TR, TER or TERC, is an ncRNA found in eukaryotes that is a component of telomerase, the enzyme used to extend telomeres. [ 3 ] [ 4 ] TERC serves as a template for telomere replication ( reverse transcription ) by telomerase.
In most multicellular eukaryotic organisms, telomerase is active only in germ cells, some types of stem cells such as embryonic stem cells, and certain white blood cells. [9] Telomerase can be reactivated and telomeres restored to the embryonic state by somatic cell nuclear transfer. [18]
21745 Ensembl ENSG00000129566 ENSMUSG00000006281 UniProt Q99973 P97499 RefSeq (mRNA) NM_007110 NM_001319035 NM_009351 RefSeq (protein) NP_001305964 NP_009041 NP_033377 Location (UCSC) Chr 14: 20.37 – 20.41 Mb Chr 14: 51.06 – 51.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene. Function This ...
The enzyme, originally called "telomere terminal transferase," is now known as telomerase. Telomerase rebuilds the tips of chromosomes and determines the life span of cells. [11] Greider's additional research to confirm her discovery was largely focused on identifying the mechanism that telomerase uses for elongation. [12]
He studies telomerase, the enzyme that copies the telomeric sequences and lengthens them. [8] The active site protein subunits of telomerase comprise a new class of reverse transcriptases, enzymes previously thought to be restricted to viruses and transposable elements. Telomerase is activated in 90% of human
TERRA-Telomerase Interaction at Long Telomeres. At cells with long telomeres, TERRA is proposed to act as a negative regulator of telomerase activity. This direct inhibitor function acts through base-pairing of the tandem repeats found throughout TERRA's 3'-end to the complementary RNA template region of telomerase. [6]