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PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response. Highly expressed in platelets and endothelial cells, PAR1 plays a key role in mediating the interplay between coagulation and inflammation , which is important in the pathogenesis of inflammatory and fibrotic lung ...
Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets , and also on endothelial cells , fibroblasts, immune cells, myocytes , neurons , and tissues that line the gastrointestinal tract.
Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs .
The ability of the immune system to recognize molecules that are broadly shared by pathogens is, in part, due to the presence of immune receptors called toll-like receptors (TLRs) that are expressed on the membranes of leukocytes including dendritic cells, macrophages, natural killer cells, cells of the adaptive immunity T cells, and B cells, and non-immune cells (epithelial and endothelial ...
Platelets are regulators of hemostasis and thrombosis. Platelets become active in the blood following vascular injury. Vascular injury causes platelets to stick to the cellular matrix that is exposed under the endothelium, form a platelet plug, and then form a thrombus. Platelets are essential in the formation of an occlusive thrombus and are ...
6915 21390 Ensembl ENSG00000006638 ENSMUSG00000034881 UniProt P21731 P30987 RefSeq (mRNA) NM_001060 NM_201636 NM_001277265 NM_009325 NM_001358512 RefSeq (protein) NP_001051 NP_963998 NP_001264194 NP_033351 NP_001345441 Location (UCSC) Chr 19: 3.59 – 3.61 Mb Chr 10: 81.16 – 81.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The thromboxane receptor (TP) also known as the ...