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Little is known about the chronic toxicity of diethyl phthalate, but existing information suggests only a low toxic potential. [6] Studies suggest that some phthalates affect male reproductive development via inhibition of androgen biosynthesis.
Glycerol, Propylene glycol, low molecular weight polyethylene glycols, phthalate derivatives like dimethyl, diethyl and dibutyl phthalate, Citrate derivatives such as tributyl, triethyl, acetyl citrate, triacetin and castor oil are some of the commonly used plasticizer excipients.
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The most common way to prepare cellulose acetate phthalate consists of the reaction of a partially substituted cellulose acetate (CA) with phthalic anhydride in the presence of an organic solvent and a basic catalyst. The organic solvents widely used as reaction media for the phthaloylation of cellulose acetate are acetic acid, acetone, or ...
Phthalates can plasticise ethyl cellulose, polyvinyl acetate phthalate (PVAP) and cellulose acetate phthalate (CAP), all of which are used to make enteric coatings for tablet and capsule medications. These coatings protect drugs from the acidity of the stomach, but allow their release and absorption in the intestines.
It can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications, e.g. as a plasticizer for film coating of tablets, beads, and granules. [2]
Bis(2-ethylhexyl) phthalate (DEHP) also commonly known as (dioctyl phthalate, [12] DOP or diethylhexyl phthalate), historically used in flooring materials, medical devices, myriad consumer products, and high explosives, such as Semtex. DEHP was the most common plasticizer for decades and still holds that title globally even as it has largely ...
Bis(2-ethylhexyl) phthalate (di-2-ethylhexyl phthalate, diethylhexyl phthalate, diisooctyl phthalate, DEHP; incorrectly — dioctyl phthalate, DIOP) is an organic compound with the formula C 6 H 4 (CO 2 C 8 H 17) 2. DEHP is the most common member of the class of phthalates, which are used as plasticizers.