Search results
Results From The WOW.Com Content Network
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
Unlike most laboratory mouse strains, the C57BL/6 drinks alcoholic beverages voluntarily. It is more susceptible than average to morphine addiction, atherosclerosis, and age-related hearing loss. [11] When compared directly to BALB/c mice, C57BL/6 mice also express both a robust response to social rewards [43] [44] and empathy. [45]
Approximately 60% of FVB Mice regardless of sex survive to two years of age. [6] By this point, approximately 60% of surviving mice show tumors/lesions. Some sudden deaths are observed in younger animals, but most die at 15 months or older. Two years is a common life expectancy in wild-type house mice.
Charles River was founded in 1947 by Henry Foster, a young veterinarian who purchased one thousand rat cages from a Virginia farm and set up a one-person laboratory in Boston overlooking the Charles River. To fulfill the regional need for laboratory animal models, he bred, fed, and cared for the animals and personally delivered them to local ...
Similar to other rodenticides, the preparation requires 3–7 days to be effective. Rather than killing rodents through internal haemorrhaging as anticoagulants do, [9] PCC affects a rodent’s digestive system, causing acute dehydration due to its extremely absorptive nature (corn cob has been used in applications such as oil spills in water bodies, seed drying and de-icing). [10]
The incidence of spontaneous diabetes in the NOD mouse is 60–80% in females and 20–30% in males. Onset of diabetes also varies between males and females: commonly, onset is delayed in males by several weeks. The mice (as well as C57BL/6 and SJL) are known to carry IgG2c allele. [4] [5]
Female mice in the dangerous living environment group, showed higher levels of fecal corticosterone, and minimal maternal care compared to the females in the safe environment group. Furthermore, a dangerous environment inherently provides infanticide threats to female mice, increasing the likelihood that corticosterone concentrations will ...