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A box model explaining the processes of toxicokinetics and toxicodynamics. While toxicokinetics describes the changes in the concentrations of a toxicant over time due to the uptake, biotransformation, distribution and elimination of toxicants, toxicodynamics involves the interactions of a toxicant with a biological target and the functional or structural alterations in a cell that can ...
Similarly, physiological toxicokinetic models are physiological pharmacokinetic models developed to describe and predict the behavior of a toxicant in an animal body; for example, what parts (compartments) of the body a chemical may tend to enter (e.g. fat, liver, spleen, etc.), and whether or not the chemical is expected to be metabolized or ...
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Internet Explorer box model bug, in the implementation of the CSS box model Topics referred to by the same term This disambiguation page lists articles associated with the title Box model .
George Edward Pelham Box FRS [1] (18 October 1919 – 28 March 2013) was a British statistician, who worked in the areas of quality control, time-series analysis, design of experiments, and Bayesian inference. He has been called "one of the great statistical minds of the 20th century".
Each box exchanges heat with the atmosphere. The atmospheric temperatures (T 1 a,T 2 a) are fixed in this model. The evaporated water (η 2 ≥ 0) in the equatorial box is precipitated, via the atmosphere, in the high-latitude box. The governing differential equations for the temperatures and salinities in the Stommel box model are:
The potential energy in this model is given as = {, < < +,,, where L is the length of the box, x c is the location of the center of the box and x is the position of the particle within the box. Simple cases include the centered box ( x c = 0) and the shifted box ( x c = L /2) (pictured).
Receptor theory is the application of receptor models to explain drug behavior. [1] Pharmacological receptor models preceded accurate knowledge of receptors by many years. [ 2 ] John Newport Langley and Paul Ehrlich introduced the concept that receptors can mediate drug action at the beginning of the 20th century.