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The risk of bleeding is increased if used at the same time as other blood thinning drugs such as nonsteroidal anti-inflammatory drugs, antiplatelet drugs and heparin. [2] The blood thinning effects can be reduced if used at the same time as rifampicin and phenytoin , and increased with fluconazole .
ATC code B01 Antithrombotic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup B01 is part of the anatomical group B Blood and blood forming ...
Apixaban was approved for medical use in the European Union in May 2011, and in the United States in December 2012. [7] [8] [14] It is on the World Health Organization's List of Essential Medicines. [15] In 2022, it was the 27th most commonly prescribed medication in the United States, with more than 19 million prescriptions.
Traditionally, however, doctors have recommended people take blood pressure medication in the morning. "Blood pressure tends to be higher during the day and lower at night, so I typically ...
Chlorthalidone is the thiazide drug that is most strongly supported by the evidence as providing a mortality benefit; in the ALLHAT study, a chlorthalidone dose of 12.5 mg was used, with titration up to 25 mg for those subjects who did not achieve blood pressure control at 12.5 mg. Chlorthalidone has repeatedly been found to have a stronger ...
The Generic Product Identifier (GPI) is a 14-character hierarchical classification system created by Wolters Kluwer's Medi-Span that identifies drugs from their primary therapeutic use down to the unique interchangeable product regardless of manufacturer or package size. The code consists of seven subsets, each providing increasingly more ...
Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. At first, it had many side effects but for the next twenty years, investigators worked on heparin to make it better and safer. It entered clinical trials in 1935 and the first drug was launched in 1936. Chains of natural heparin can vary from 5.000 to 40. ...
Types of drug Common Examples Mechanism of benefit and effect Side effects, caution & contraindications Remarks Beta-blockers: Metoprolol; Atenolol; Bisoprolol; Block beta-1 receptors in the heart → stop the effects of catecholamines on the heart→ reduce heart rate, heart contractility and conduction velocity → reduce the workload of the ...