Search results
Results From The WOW.Com Content Network
Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder. [27] [page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder. [25] [28] Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.
Very common (10-100% incidence) adverse effects include: Nausea; Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs. [5] [page needed] Impaired ...
Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [182] [183] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from the ...
Paroxetine was the first drug to be FDA-approved for this disorder. Its efficacy is considered beneficial, although not everyone responds favorably to the drug. Sertraline and fluvoxamine extended-release were later approved for it as well, while escitalopram is used off-label with acceptable efficiency.
As demonstrated in table 2, paroxetine also inhibits the NOSs enzyme which could be the reason for its sexual dysfunction adverse effect, especially in men. [18] Paroxetine shows the highest affinity for muscarinic receptors of all the SSRIs which results in weak anticholinergic activity and therefore undesirable adverse effects. [44]
First generation antihistamines have the ability to cross the blood-brain barrier which can result in sedative and anticholinergic effects while effectively treating allergic reactions and nausea and vomiting related to pregnancy. On the other hand, second generation antihistamines do not cross the blood-brain barrier, thus eliminating sedating ...
Like other medications for the treatment of (ED), Cialis — and its generic version, tadalafil — can cause adverse effects at first. Fortunately, most tadalafil side effects are mild and ...
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]