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The AP-1 transcription factor also has been shown to be involved in breast cancer cell growth through multiple mechanisms, including regulation of cyclin D1, E2F factors and their target genes. c-Jun, which is one of the AP-1 subunits, regulates the growth of breast cancer cells.
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor ...
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. [1] The AP-1 binding site, in humans, has a nucleotide sequence of ATGAGTCAT, where A corresponds to adenine , T corresponds to thymine , G corresponds to guanine , and C corresponds to cytosine .
It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts ...
The best known class of these complexes is composed of NFAT and AP-1 or other bZIP proteins. This NFAT:AP-1 complex binds to the conventional Rel-family proteins DNA binding sites and is involved in gene transcription in immune cells. [13] [3]
HDACs 1 and 2 can also bind directly to DNA binding proteins such as Yin and Yang 1 (YY1), Rb binding protein 1 and Sp1. [5] HDACs 1 and 2 have been found to express regulatory roles in key cell cycle genes including p21. [6] Activity of these HDACs can be affected by phosphorylation.
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1174 11769 Ensembl ENSG00000106367 ENSMUSG00000004849 UniProt P61966 P61967 RefSeq (mRNA) NM_057089 NM_001283 NM_007457 RefSeq (protein) NP_001274 NP_031483 Location (UCSC) Chr 7: 101.15 – 101.16 Mb Chr 5: 137.06 – 137.07 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. Function The protein ...