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The protracted withdrawal syndrome from benzodiazepines, opioids, alcohol and other addictive substances can produce symptoms identical to generalized anxiety disorder as well as panic disorder. Due to the sometimes prolonged nature and severity of benzodiazepine, opioid and alcohol withdrawal, abrupt cessation is not advised.
Premature babies with NAS tend to recover at a much faster rate than a full term baby would. [ 4 ] Both neonatal and maternal factors such as gestational age (length of pregnancy starting from the first day of the last mentrual period), maternal substance use, genetics, and gender play a role in the symptoms expressed by the neonate. [ 9 ]
There is a slight increase in dose proportionality in terms of peak and area-under-the-curve levels of THC with increasing oral doses over a range of 2.5 to 10 mg. [22] A high-fat meal delays time to peak concentrations of oral THC by 4 hours on average and increases area-under-the-curve exposure by 2.9-fold, but peak concentrations are not ...
A 2020 study published in the Journal of Translational Medicine noted that THC—the main psychoactive ingredient in cannabis—has been noted to increase anxiety, while CBD—a cannabis ...
Cannabis is often used by people to cope with anxiety, yet the efficacy and safety of cannabis for treating anxiety disorders is yet to be researched. [40] [41] Cannabis use, especially at high doses, is associated with a higher risk of psychosis, particularly in individuals with a genetic predisposition to psychotic disorders like schizophrenia.
Overdose and death may occur with a single oral dose of between 100 and 150 mg of morphine in a healthy adult who has no tolerance to opiates. [35] [36] This represents the equivalent of between two and three teaspoons (10–15 mL) of opium tincture. Suicide by laudanum was common in the mid-19th century. [37]
THC morpholinylbutyrate (SP-111, Δ 9-THC-O-[4-(morpholin-4-yl)butyrate]) is a synthetic derivative of tetrahydrocannabinol, developed in the 1970s.It is a prodrug which is converted into THC inside the body, and was one of the first derivatives of THC that is able to form water-soluble salts, giving it a significant advantage over THC for some applications.
People sometimes use cannabis to cope with their anxiety, and cannabis withdrawal can lead to symptoms of anxiety. [58] Buspirone, a serotonin 5-HT 1A receptor partial agonist, has shown limited efficacy for treating anxiety in people with cannabis use disorder, though there may be better efficacy in males than in females. [58]