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Positron emission tomography (PET) [1] is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption.
A Patlak plot (sometimes called Gjedde–Patlak plot, Patlak–Rutland plot, or Patlak analysis) [1] [2] is a graphical analysis technique based on the compartment model that uses linear regression to identify and analyze pharmacokinetics of tracers involving irreversible uptake, such as in the case of deoxyglucose.
Studies using positron emission tomography scanning of adult humans have shown that brown adipose tissue is still present in most adults in the upper chest and neck (especially paravertebrally). The remaining deposits become more visible (increasing tracer uptake, meaning more metabolically active) with cold exposure, and less visible if an ...
Diagnostic tests in nuclear medicine exploit the way that the body handles substances differently when there is disease or pathology present. The radionuclide introduced into the body is often chemically bound to a complex that acts characteristically within the body; this is commonly known as a tracer. In the presence of disease, a tracer will ...
where, within the tissue region-of-interest from the PET image, C bone (T) is the bone tissue activity concentration of tracer (in units: MBq/ml) at any time T, C plasma (T) is the plasma concentration of tracer (in units: MBq/ml) at time T, V o is the fraction of the ROI occupied by the ECF compartment, and () is the area under the plasma ...
Functional imaging (or physiological imaging) is a medical imaging technique of detecting or measuring changes in metabolism, blood flow, regional chemical composition, and absorption.
The uptake of [18 F]FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After [18 F]FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of [18 F]FDG within the body.
The greatest benefit of PET scanning is that different compounds can show flow and oxygen, and glucose metabolism in the tissues of the working brain. These measurements reflect the amount of brain activity in the various regions of the brain and allow us to learn more about how the brain works.