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TCA overdose may occur by accident or purposefully in an attempt to cause death. [2] The toxic dose depends on the specific TCA. [2] Most are non-toxic at less than 5 mg/kg except for desipramine, nortriptyline, and trimipramine, which are generally non-toxic at less than 2.5 mg/kg. [5] [2] In small children one or two pills can be fatal. [6]
The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...
Along with the discovery and introduction of the monoamine oxidase inhibitor iproniazid as an antidepressant around the same time, imipramine resulted in the establishment of monoaminergic drugs as antidepressants. [73] [74] [72] In the late 1950s, imipramine was the first TCA to be developed (by Ciba).
Amoxapine, sold under the brand name Asendin among others, is a tricyclic antidepressant (TCA). It is the N-demethylated metabolite of loxapine.Amoxapine first received marketing approval in the United States in 1980, approximately 10 to 20 years after most of the other TCAs were introduced in the United States.
Traumatic cardiac arrest (TCA) is a condition in which the heart has ceased to beat due to blunt or penetrating trauma, such as a stab wound to the thoracic area. [1] It is a medical emergency which will always result in death without prompt advanced medical care. Even with prompt medical intervention, survival without neurological ...
TCA may refer to: Chemistry and biochemistry. Toxin complex a, an insecticidal toxin complex produced by Photorhabdus luminescens bacteria;
Reducing body temperature extends the time interval that such stoppage can be survived. [2] At a brain temperature of 14 °C, blood circulation can be safely stopped for 30 to 40 minutes. [ 3 ] There is an increased incidence of brain injury at times longer than 40 minutes, but sometimes circulatory arrest for up to 60 minutes is used if life ...
[2] [6] [4] Treatment may include restarting the medication and slowly decreasing the dose. [2] People may also be switched to the long-acting antidepressant fluoxetine which can then be gradually decreased. [6] Approximately 15–50% of people who suddenly stop an antidepressant develop antidepressant discontinuation syndrome.