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Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase.It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R).
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named " just another kinase " 1 and 2 (since they were just two of many discoveries in a PCR -based screen of kinases), [ 1 ] but were ultimately published as "Janus kinase".
The JAK-STAT system consists of three main components: (1) a receptor (green), which penetrates the cell membrane; (2) Janus kinase (JAK) (yellow), which is bound to the receptor, and; (3) Signal Transducer and Activator of Transcription (STAT) (blue), which carries the signal into the nucleus and DNA. The red dots are phosphates.
This page was last edited on 25 January 2009, at 18:16 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
54721 Ensembl ENSG00000105397 ENSMUSG00000032175 UniProt P29597 Q9R117 RefSeq (mRNA) NM_003331 NM_001205312 NM_018793 RefSeq (protein) NP_003322 NP_001192241 NP_061263 Location (UCSC) Chr 19: 10.35 – 10.38 Mb Chr 9: 21.02 – 21.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. TYK2 ...
Jak 2 may refer to: Jak II, a 2003 video game; JAK2, or Janus kinase 2, an enzyme This page was last edited on 5 ...
This page was last edited on 5 November 2022, at 19:11 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
[8] [9] [10] It is a janus kinase (JAK) inhibitor, [8] [9] discovered and developed by the National Institutes of Health and Pfizer. Common side effects include diarrhea, headache, and high blood pressure. [10] Serious side effects may include infections, cancer, and pulmonary embolism.