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The cost of modafinil varied depending on factors such as location and insurance coverage; [217] [218] [219] still, in 2004, the price of modafinil in the US was around $120 or more per monthly supply. [217]
A Cephalon-founded study in which patients were administered modafinil, methylphenidate, and a placebo found that modafinil produces "psychoactive and euphoric effects and feelings consistent with [methylphenidate]." [12] Like modafinil, armodafinil is an inhibitor and/or inducer of certain cytochrome P450 enzymes.
Double-blind randomized controlled trials have demonstrated the efficacy and tolerability of modafinil in pediatric ADHD. [102] [103] There are risks of serious side effects such as skin reactions, however these are rare and modafinil is not recommended for use in children.
Modafinil analogues acting as DRIs include both drugs similar to modafinil that affect dopamine without causing stimulant effects (atypical modafinil-like non-psychostimulant DRIs) such as flmodafinil and JJC8-016 and drugs that affect dopamine in a way similar to cocaine (classical or typical cocaine-like DRIs) such as JJC8-088.
Modafinil is sold under the brand name Provigil among others. Modafinil is used to treat excessive daytime sleepiness due to narcolepsy , shift work sleep disorder , or obstructive sleep apnea . While it has seen off-label use as a purported cognitive enhancer, the research on its effectiveness for this use is not conclusive. [ 167 ]
Flmodafinil (developmental code names CRL-40,940, NLS-4, JBG01-41), also known as bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical conditions.
Wellbutrin vs Adderall: Differences and Similarities Anxiety and depression are two common mental conditions — it’s estimated that about 40 million adults deal with anxiety and an estimated 21 ...
Unlike armodafinil ((R)-(–)-modafinil), esmodafinil has never been marketed on its own. [ 3 ] Esmodafinil is suspected to be less clinically useful for treating conditions that modafinil and armodafinil are marketed for, such as narcolepsy , shift work sleep disorder , and obstructive sleep apnea .