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Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
Subcutaneous injection sites. Commonly used injection sites include: [3]: 723 The outer area of the upper arm. The abdomen, avoiding a 2-inch circle around the navel. The front of the thigh, between 4 inches from the top of the thigh and 4 inches above the knee. The upper back. The upper area of the buttock, just behind the hip bone.
It is usually a depot injection, either subcutaneous or intradermal, and not an intramuscular injection. After deposition, the drug then diffuses slowly from the depot into the capillary networks, where it enters circulation. Skin popping is distinct from intravenous injection in that the latter deposits the drug directly into the bloodstream ...
A Med-E-Jet vaccination gun from 1980. A jet injector, also known as a jet gun injector, air gun, or pneumatic injector, is a medical instrument that uses a high-pressure jet of liquid medication to penetrate the skin and deliver medication under the skin without a needle.
For certain substances, administration via an ID route can result in a faster systemic uptake compared with subcutaneous injections, [1] leading to a stronger immune response to vaccinations, immunology [clarification needed] and novel cancer treatments, and faster drug uptake. [2]
Lipohypertrophy usually will gradually disappear over months if injections in the area are avoided. It is a common misconception that the lump is largely scar tissue, as injection site hypertrophy is much rarer and milder with injections of other hormones and medications which lack the specific ability of insulin to stimulate adipose hypertrophy.
For instance, in February 2022, the U.S. FDA approved generic Apokyn (apomorphine hydrochloride injection) drug cartridges for treating hypomobility and other advanced Parkinson's disease symptoms. Similarly, in January 2021, Novartis AG invested in Credence MedSystems to assist in developing and scaling its drug delivery systems.
The desired injection site and the skin profile at the injection site will determine what needle length is appropriate for a person to use. [23] For products with included needles, such as epinephrine pens, different brands may have different included needle lengths, which must be taken into account.