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Gadoteridol is a gadolinium-based MRI contrast agent, used particularly in the imaging of the central nervous system. It is sold under the brand name ProHance . [ 3 ] Gadoteridol was first approved for use in the United States in 1992.
MRI contrast agents are contrast agents used to improve the visibility of internal body structures in magnetic resonance imaging (MRI). [1] The most commonly used compounds for contrast enhancement are gadolinium-based contrast agents (GBCAs).
Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA).It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine).
Gadobutrol showed higher sensitivity than ProHance for the determination of lesion malignancy; Gadobutrol-enhanced images were consistently favored over ProHance-enhanced images by all 3 blinded readers; Prior to approval for use in children under the age of 2 years old in 2015, a phase 1 clinical trial was conducted.
Gadodiamide is one of the main GBCA associated with nephrogenic systemic fibrosis (NSF), a toxic reaction occurring in some people with kidney problems. [6] No cases have been seen in people with normal kidney function.
Gadopentetic acid, sold under the brand name Magnevist, is a gadolinium-based MRI contrast agent. [2]It is usually administered as a salt of a complex of gadolinium with DTPA (diethylenetriaminepentacetate) with the chemical formula A 2 [Gd(DTPA)(H 2 O)]; when cation A is the protonated form of the amino sugar meglumine the salt goes under the name "gadopentetate dimeglumine".
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Gadobenic acid (INN, brand name Multihance) is a complex of gadolinium with the ligand BOPTA. In the form of the methylglucamine salt meglumine gadobenate or gadobenate dimeglumine (), it is used as a gadolinium-based MRI contrast medium.