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Daflon is under preliminary research for its potential use in treating vein diseases, [5] or hemorrhoids. [6] It is sold as a drug in France, [7] [8] Spain, [9] Malaysia [10] [11] and Belgium. There is moderate certainty evidence for the effectiveness of daflon for slightly reducing oedema compared to placebo in the treatment of chronic venous ...
Thromboxane A2 Thromboxane B2. Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ether-containing ring. Thromboxane is named for its role in blood clot formation .
11-Dehydrothromboxane B2 (or 11-dehydro-TXB2) is produced from the breakdown of thromboxane A2.It is released by activated platelets and urine levels of 11-dehydro-TXB2 can be used to monitor the response to aspirin therapy when used to prevent heart disease [1] and in diseases where platelet activation is prominent.
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). [1] 2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro. [2]
Thromboxane A 2 (TXA 2) is generated from prostaglandin H 2 by thromboxane-A synthase in a metabolic reaction which generates approximately equal amounts of 12-hydroxyheptadecatrienoic acid (12-HHT). Aspirin irreversibly inhibits platelet cyclooxygenase 1 preventing the formation of prostaglandin H 2, and therefore TXA 2.
Skeletal formula of thromboxane B2. Created using ACD/ChemSketch 10.0 and Inkscape. Style made to match Image:Leukotriene A4.svg and others by Calvero. Date: 1 May 2007: Source: Own work: Author: Fvasconcellos 16:46, 1 May 2007 (UTC) Permission (Reusing this file)
U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH 2 first prepared in 1975, [1] and acts as a thromboxane A 2 (TP) receptor agonist. It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations and exhibits many properties similar to thromboxane A 2, including shape change and aggregation of ...
Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s). [1] Their main role is to catalyze the transformation of arachidonic acid into the intermediate prostaglandin H2 , which is the precursor of a variety of prostanoids ...