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Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a rare autoimmune disease in which widespread, intravascular clotting causes multi-organ failure. [1] The syndrome is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with phospholipids .
Antiphospholipid syndrome is known for causing arterial or venous blood clots, in any organ system, and pregnancy-related complications.While blood clots and pregnancy complications are the most common and diagnostic symptoms associated with APS, other organs and body parts may be affected like platelet levels, heart, kidneys, brain, and skin.
Catastrophic antiphospholipid syndrome: Protein S deficiency: Autoimmune disorder i.e. APS Factor V Leiden: Illness that causes or promote tissue necrosis: Prothrombin mutation: Malignancy: Antithrombin deficiency: Pregnancy Immobility Surgery Trauma Thrombocytopenic purpura
Cataract-microcornea syndrome; Catastrophic antiphospholipid syndrome; Catel–Manzke syndrome; Cauda equina syndrome; Caudal regression syndrome; CDK13-related disorder; Celebrity worship syndrome; Central centrifugal cicatricial alopecia; Central cord syndrome; Central nervous system syndrome; Central pain syndrome; Centurion syndrome
Schematic representation of antibody. Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, [1] antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, [2] idiopathic spontaneous abortion, [3] and systemic lupus erythematosus (SLE). [4]
"Cutaneous microvascular occlusion syndrome as the first manifestation of catastrophic lupus-associated antiphospholipid antibody syndrome: a case report". Journal of Medical Case Reports. 17 (1). doi: 10.1186/s13256-023-04068-9. ISSN 1752-1947. PMC 10464427. PMID 37605287. Ko, Christine J.; Gehlhausen, Jeff R.; McNiff, Jennifer M. (2021).
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome; Canities subita; Cannabinoid hyperemesis syndrome; Cardiocranial syndrome, Pfeiffer type; Cardiovascular syndrome; Catastrophic antiphospholipid syndrome; CDAGS syndrome; Central centrifugal cicatricial alopecia; Central nervous system syndrome; Cervicocranial syndrome; Chiari–Frommel ...
Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis and complications during pregnancy, often leading to fetal death. It is caused by the presence of antibodies against anionic phospholipids and β2-glycoprotein I (β2GPI). The anti-β2GPI antibodies are most prevalent in causing the symptoms of the disease.