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The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.
Rare (<0.1%) adverse effects include: Urinary retention; Prolonged QT interval; Torsades de Pointes; Ataxia; Breast enlargement or engorgement; Lactation; Cardiospasm
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While the disease isn’t directly life-threatening when it’s well-managed, people with this condition have a 43 percent higher risk of death from vascular problems, 60 percent higher risk of ...
The most common side effects include hypertension (high blood pressure), vascular access thrombosis (formation of blood clots in the blood vessels associated with dialysis), diarrhea, peripheral edema (swelling especially of the ankles and feet), hyperkalemia (high blood potassium levels) and nausea (feeling sick).
A recent study reveals some women over 70 years old are felling more lonely than ever due to the COVID-19 pandemic. Study Says Some Woman Over 70 Suffering Through 'The Silent Epidemic' Due To ...
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging process itself because all adult animals age ( with rare exceptions ) but not all adult animals ...
One study found the median age at diagnosis to be 60 years, [9] while a Mayo Clinic study in Olmsted County, Minnesota found that the highest incidence was in people aged 70–79 years. [40] The overall incidence in the Minnesota population was 1.9 per 100,000 person-years, and the disease was more common in men than women. [40]