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Ankylosing spondylitis (AS) is a type of arthritis from the disease spectrum of axial spondyloarthritis. [5] It is characterized by long-term inflammation of the joints of the spine, typically where the spine joins the pelvis. [2] With AS, eye and bowel problems—as well as back pain—may occur. [2]
The spectrum of axial involvement includes true ankylosing spondylitis, which is characterized by classic clinical and radiologic features, as well as asymptomatic sacroiliitis and inflammatory pain in the lower back regardless of the radiological evidence of the condition. Axial involvement may occur years before bowel disease.
Since the disease ankylosing spondylitis was still defined by the Modified New York criteria of 1984, there was the need to find a new disease term that would also include the less severe forms or early onset of ankylosing spondylitis. This expression was found in the umbrella term axial spondyloarthritis.
Radiculopathy is characterized by sensory and motor disturbances, such as severe pain in the neck, shoulder, arm, back, or leg, accompanied by muscle weakness. Less commonly, direct pressure on the spinal cord (typically in the cervical spine) may result in myelopathy , characterized by global weakness, gait dysfunction, loss of balance, and ...
Microscopically visible ileal inflammation is seen in about 50% of people with spondyloarthritis and ankylosing spondylitis during ileocolonoscopy. [11] [4] There seems to be an immunological connection between the gut inflammation observed in Crohn's disease and ankylosing spondylitis. [12]
When involving inflammation, it can be called spondylitis. In contrast, a spondyloarthropathy is a condition involving the vertebral joints, but many conditions involve both spondylopathy and spondyloarthropathy. Examples include ankylosing spondylitis and spondylosis.
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[16] [8] [17] [18] [19] Research demonstrates that diseases, such as ankylosing spondylitis and calcific tendinitis, [20] also have to be taken into consideration. Experimental studies have demonstrated how loading history (physical activity) can increase the relative size of muscle attachment sites.
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