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A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups. In a nucleoside, the anomeric carbon is linked through a glycosidic bond to the N9 of a purine or the N1 of a ...
Examples of these include cytidine, uridine, adenosine, guanosine, thymidine and inosine. Subcategories This category has the following 2 subcategories, out of 2 total.
Some nucleoside analogues, however, can function both as NRTIs and polymerase inhibitors for other viruses (e.g., hepatitis B). Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, e.g. gemcitabine. They are also used as antiplatelet drugs to prevent the formation of blood clots, ticagrelor and cangrelor.
Because most heterocyclic bases contain multiple nucleophilic sites, site selectivity is an important issue in nucleoside synthesis. Purine bases, for instance, react kinetically at N 3 and thermodynamically at N 1 (see Eq. (4)). [4] Glycosylation of thymine with protected 1-acetoxy ribose produced 60% of the N 1 nucleoside and 23% of the N 3 ...
A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose), with three phosphate groups bound to the sugar. [1] They are the molecular precursors of both DNA and RNA , which are chains of nucleotides made through the processes of DNA replication and transcription . [ 2 ]
Quantity (common name/s) (Common) symbol/s Defining equation SI units Dimension Number of atoms N = Number of atoms remaining at time t. N 0 = Initial number of atoms at time t = 0
Carbocyclic nucleosides (also referred to as carbanucleosides) are nucleoside analogues in which a methylene group has replaced the oxygen atom of the furanose ring. [1] These analogues have the nucleobase attached at a simple alkyl carbon rather than being part of a hemiaminal ether linkage. As a result, they have increased chemical stability.
A ribonucleoside is a type of nucleoside including ribose as a component. [1] One example of a ribonucleoside is cytidine. [2] References