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2013 – The first NS5B polymerase inhibitor sofosbuvir approved. Dasabuvir was approved in 2014. [28] 2014 – The first NS5A inhibitor ledipasvir was approved. Four other NS5A inhibitors of this class—daclatasvir, ombitasvir, elbasvir and velpatasvir—have been subsequently approved. [28]
HCV genome. Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). [1] It is an RNA-dependent RNA polymerase, having the key function of replicating HCV's viral RNA by using the viral positive RNA strand as a template to catalyze the polymerization of ribonucleoside triphosphates (rNTP) during RNA replication.
The NS5B protein is a RNA-dependent RNA ... Remdesivir—a nucleotide analogue RNA polymerase inhibitor originally intended to treat hepatitis C that uses ...
Pages in category "NS5B (polymerase) inhibitors" The following 13 pages are in this category, out of 13 total. This list may not reflect recent changes. ...
PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors that was created by chemist Jeremy L. Clark. [1] Specifically, PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B. [2] PSI-6130 is currently being developed by Hoffmann–La Roche as a 3',5'-diisobutyrl ester prodrug, R7128 ...
Ledipasvir works by decreasing the activity of NS5A and sofosbuvir works by decreasing the activity of NS5B polymerase. [8] Ledipasvir/sofosbuvir was approved for medical use in the United States, in the European Union, and in Canada in 2014. [8] [11] [7] [12] [13] It is on the World Health Organization's List of Essential Medicines. [14]
Uprifosbuvir (MK-3682) is an antiviral drug developed for the treatment of hepatitis C.It is a nucleotide analogue which acts as an NS5B RNA polymerase inhibitor. As of 2019 it was in Phase III human clinical trials.
It is given as a single daily pill containing daclatasvir, a viral NS5A inhibitor, [3] and sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase NS5B. [4] It is on the World Health Organization's List of Essential Medicines. [5]