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Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell ...
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD + ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] It is the most abundant of the PARP family of enzymes, accounting for 90% of the NAD+ used by the family. [6]
PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are developed for multiple indications, including the treatment of heritable cancers. [1] Several forms of cancer are more dependent on PARP than regular cells, making PARP (PARP1, PARP2 etc.) an attractive target for cancer therapy.
11546 Ensembl ENSG00000129484 ENSMUSG00000036023 UniProt Q9UGN5 O88554 RefSeq (mRNA) NM_001042618 NM_005484 NM_009632 RefSeq (protein) NP_001036083 NP_005475 NP_033762 Location (UCSC) Chr 14: 20.34 – 20.36 Mb Chr 14: 51.05 – 51.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of ...
547253 Ensembl ENSG00000173193 ENSMUSG00000034422 UniProt Q460N5 Q8N546 Q2EMV9 RefSeq (mRNA) NM_017554 NM_001039530 RefSeq (protein) NP_060024 NP_060024.2 NP_001034619 Location (UCSC) Chr 3: 122.68 – 122.73 Mb Chr 16: 35.65 – 35.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 ...
Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene. [ 5 ] [ 6 ] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction.
Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene. [5] [6] Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM] [6]
Poly(ADP-ribose) polymerase-1 is a nuclear enzyme that is found universally in all eukaryotes and is encoded by the PARP-1 gene.It belongs to the PARP family, which is a group of catalysts that transfer ADP-ribose units from NAD (nicotinamide dinucleotide) to protein targets, thus creating branched or linear polymers. [4]