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Parkinson's disease (PD) is a neurodegenerative disease affecting both the central and peripheral nervous systems, characterized by the loss of dopamine-producing neurons in the substantia nigra region of the brain. [5]
According to the Journal of the History of the Neurosciences, Dr. Lewy became interested in studying more about the brain , because of the discovery that Alois Alzheimer made in 1906. The article mentions that the third reported case of Alzheimer's disease had histological structures that happened to be similar to Lewy body histology slides ...
A brain tissue with Lewy bodies. The first major proposed cause of neuronal death in Parkinson's disease is the bundling, or oligomerization, of proteins.The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates to form Lewy bodies (shown to left) in neurons.
Although Parkinson's disease is primarily a disease of the nigrostriatal pathway and not the extrapyramidal system, loss of dopaminergic neurons in the substantia nigra leads to dysregulation of the extrapyramidal system. Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's.
The three subgroups of Parkinson’s identified by the machine learning are based on the pace of the disease’s progression: Rapid Pace (PD-R), which is marked by rapid progression of symptoms.
Parkinson’s disease was correlated with genes linked to intracranial and subcortical brain volumes. ADHD, insomnia , and neuroticism were negatively correlated with genes controlling ...