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319229 Ensembl ENSG00000080293 ENSMUSG00000026387 UniProt P47872 Q5FWI2 RefSeq (mRNA) NM_002980 NM_001012322 NM_001311077 RefSeq (protein) NP_002971 NP_001012322 NP_001298006 Location (UCSC) Chr 2: 119.44 – 119.53 Mb Chr 1: 119.93 – 119.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is ...
Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands . [ 5 ]
The currently known superfamily members include the rhodopsin-like GPCRs (this family), the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs. [3]
The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors , making the Adhesion subfamily the more basal group. [ 6 ]
Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, prealbumin, peptide HI-27, and growth hormone releasing factor. Human hormones from this family
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a peptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors. [5]
Gastrinoma cells release gastrin in response to secretin stimulation, [12] [13] thereby providing a sensitive means of differentiation. Fasting gastrin levels on at least three occasions [ 14 ] Gastric acid secretion and pH (normal basal gastric acid secretion is less than 10 mEq/hour; in Zollinger–Ellison patients, it is usually more than 15 ...