Search results
Results From The WOW.Com Content Network
Persons with nephrogenic diabetes insipidus must consume enough fluids to equal the amount of urine produced. Any underlying cause such as high blood calcium must be corrected to treat nephrogenic diabetes insipidus. The first line of treatment is hydrochlorothiazide and amiloride. [10] Patients may also consider a low-salt and low-protein diet.
The causes of SIADH are commonly grouped into categories including: central nervous system diseases that directly stimulate the hypothalamus to release ADH, various cancers that synthesize and secrete ectopic ADH, various lung diseases, numerous drugs that may stimulate the release of ADH, enhance ADH effects, act as ADH analogues in the body ...
Application of this name to DI arose from the fact that diabetes insipidus does not cause glycosuria (excretion of glucose into the urine). In a large survey conducted amongst patients with central diabetes insipidus, the majority were in favor of changing the disease's name to "vasopressin deficiency" to avoid confusion with diabetes mellitus. [6]
Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. Nephrogenic diabetes insipidus occurs when the kidney is unable to concentrate urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate.
The use in SIADH actually relies on a side effect; demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). [ 10 ] [ 12 ] [ 13 ] The use of demeclocycline in SIADH was first reported in 1975, [ 14 ] and, in 1978, a larger study found it to be more effective and better tolerated than lithium ...
The drug is now marketed by Cumberland Pharmaceuticals, Inc. Conivaptan inhibits two of the three subtypes of the vasopressin receptor (V1a and V2). Effectively, it causes iatrogenic nephrogenic diabetes insipidus. Conivaptan has not been approved by the American Food and Drug Administration for the treatment of decompensated congestive heart ...
Think about the healthy life years you gain just from minimizing these risks, considering lung cancer and heart disease are by far the leading causes of premature deaths among men and women in the US.
Thiazides can be used to paradoxically decrease urine flow in people with nephrogenic diabetes insipidus. [16] Thiazides may also be useful in treating hyponatremia (low blood sodium) in infants with central diabetes insipidus. [17]