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Klinefelter syndrome is not an inherited condition. The extra X chromosome comes from the mother in approximately 50% of the cases. Maternal age is the only known risk factor. Women at 40 years have a four-times-higher risk of a child with Klinefelter syndrome than women aged 24 years. [14] [34] [35]
Normal life expectancy [2] Frequency ~1 in 1,000 males [1] ... In contrast to the other common sex chromosome aneuploidies—47,XXX and 47,XXY (Klinefelter syndrome) ...
Severe internal disease is rare in trisomy X. Genitourinary conditions are more common than in the general population, particularly kidney and ovary malformations. [3] The autoimmune disease SLE is more common in women than men by a factor of 9 and the risk is further exacerbated in Trisomy X by a factor of approximately 2.5.
Life expectancy in the U.S. is projected to increase from 78.3 years in 2022 to 79.9 years in 2035 and to 80.4 years in 2050 for all sexes combined, researchers said. ... from 49th in 2022 to 66th ...
Life expectancy may be plateauing. ... prevent up to 900,000 infants from having low birth weight and result in 1,500 fewer premature deaths a year from heart disease.
From 2019 to 2021, U.S. life expectancy dropped from 78.8 years to 7 6.4. Covid deaths fell significantly last year: Whereas Covid was the fourth leading cause of death in 2022, it was the 10th in ...
It can be considered a form or variant of Klinefelter syndrome (47,XXY). [11] Individuals with this syndrome are typically mosaic, being 49,XXXXY/48, XXXX. [4] It is genetic but not hereditary, meaning that while the genes of the parents cause the syndrome, there is a small chance of more than one child having the syndrome.
Like Klinefelter syndrome, the presence of additional X chromosomes affects the male reproductive system, can cause physical abnormalities, and can affect cognitive development. When comparing 47,XXY and 48,XXXY, there is a greater risk for congenital malformations and more medical problems in those with 48,XXXY. [2]