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Phenacetin (/ f ɪ ˈ n æ s ɪ t ɪ n / ⓘ; acetophenetidin, N-(4-ethoxyphenyl)acetamide [1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [ 2 ] and by the U.S. Food and Drug ...
Trademarked in 1918, Anacin is one of the oldest brands of pain relievers in the United States. It originally contained acetophenetidin (phenacetin) and was promoted as "aspirin-free relief," but was reformulated in the 1980s following the FDA's ruling to withdraw phenacetin from the market in 1983 due to concerns over its carcinogenic properties.
Publix is ending a popular program that makes some prescriptions drugs available for free, according to reports. “While we are no longer offering medications for free, many will still be ...
Another example is Bex, a once popular Australian compound analgesic which is no longer sold. It contained 42% aspirin, 42% phenacetin, plus caffeine. [2]The United States Food and Drug Administration also now requires that manufacturers of compound analgesics unequivocally state each ingredient's purpose.
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Compound analgesics were banned in Australia in 1979 due to analgesic nephropathy. [8] Phenacetin, a pain-relieving and fever-reducing drug, was banned by the FDA in the US in 1983, due to its adverse effects, which include kidney damage (as shown by Dr. Priscilla Kincaid-Smith) [9] [10] and cancer. [11]
Diversion, abuse, and a relatively high rate of overdose deaths in comparison to other drugs of its group. This drug continues to be available in most of the world including the US, but under strict controls. Terfenadine (Seldane, Triludan) 1997–1998 France, South Africa, Oman, others, US Prolonged QT interval; ventricular tachycardia [2] [3]
It often contained aspirin, phenacetin and caffeine, but was reformulated in 1981, replacing the original ingredient phenacetin with paracetamol, before phenacetin was banned by the US FDA in 1983. It was available in more than 80 countries across Europe, Latin America, Asia and Africa, but has been discontinued in many of them.