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Nance–Horan syndrome, also known as X-linked congenital cataracts and microcornea, X-linked cataract–dental syndrome, cataracts-oto-dental syndrome, cataract–dental syndrome, and mesiodens–cataract syndrome, is a rare X-linked syndrome characterized by eye and teeth abnormalities, intellectual disability, and facial deformities.
In 2022, a retrospective study conducted on 82 eyes with OOKP using original Strampelli technique, showed an anatomical survival of 94% up to 30 years of follow-up. The same study also reported a visual acuity better than 1.00 logMAR (or 20/200 Snellen) at 10 years in 81% of the eyes, and a visual acuity of 1.21 logMAR (or 20/324 Snellen) at 30 ...
A cataract is a cloudy area in the lens of the eye that leads to a decrease in vision of the eye. [ 1 ] [ 7 ] Cataracts often develop slowly and can affect one or both eyes. [ 1 ] Symptoms may include faded colours, blurry or double vision , halos around light, trouble with bright lights, and difficulty seeing at night . [ 1 ]
At some point—usually as you enter middle age—most people develop this eye condition, which is a clouding of the eye’s lens that can get progressively worse and impair your vision.
Teeth with large roots (radiculomegaly), heart defects and small eyes (microphthalmia) are the characteristic triad found in this syndrome. Typical features of the condition include: [citation needed] Face Deep set eyes; Broad nasal tip divided by a cleft; Eyes Microphthalmia (small eyes) Early cataracts; Glaucoma; Teeth
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.
Aphakia is the absence of the lens of the eye, due to surgical removal, such as in cataract surgery, a perforating wound or ulcer, or congenital anomaly. It causes a loss of ability to maintain focus ( accommodation ), high degree of farsightedness ( hyperopia ), [ 1 ] and a deep anterior chamber .
Cataract surgery is the removal of the natural lens of the eye that has developed a cataract, an opaque or cloudy area. [3] Over time, metabolic changes of the crystalline lens fibres lead to the development of a cataract, causing impairment or loss of vision.