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Doctors stress the importance of talking to your health care provider before putting yourself on a daily dose of baby aspirin, which is typically 81 milligrams.
Nearly one in three Americans over the age of 60 — roughly 19 million people — take aspirin daily, according to a 2021 study in the Annals of Internal Medicine. And more than three million ...
Aspirin "weakens the stomach's protective lining against stomach acid, making the stomach and intestines more vulnerable to ulcers, which can bleed," according to Harvard Health.
Aspirin taken at doses of ≤325 mg and ≤100 mg per day for ≥2 days can increase the odds of suffering a gout attack by 81% and 91% respectively. This effect may potentially be worsened by high purine diets, diuretics, and kidney disease, but is eliminated by the urate lowering drug allopurinol. [ 184 ]
Risk of adverse advents such as bleeding or gastrointestinal side effects is relatively high with daily aspirin therapy. Even a 81 mg daily aspirin regimen for cardiovascular benefits has been shown to increase risk of long-term bleeding, [27] so the significantly higher aspirin doses used for maintenance therapy are of some concern. [19]
The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass. [12] Moderate toxicity occurs at doses up to 300 mg/kg, severe toxicity occurs between 300 and 500 mg/kg, and a potentially lethal dose is greater than 500 mg/kg. [ 13 ]