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Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain . [ 2 ]
Common side effects include pneumonia and urinary tract infections. [9] Severe side effects may include blood clots or cardiac arrest. [9]Andexanet alfa has a boxed warning that it is associated with arterial and venous blood clots, ischemic events, cardiac arrest, and sudden deaths.
Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
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Trodusquemine is an aminosterol (polyamine steroid conjugate) that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. [1] The compound exhibits broad-spectrum antimicrobial activity [2] and numerous regenerative, neuroprotective, anti-atherosclerotic, antitumor, antiangiogenic, antiobesity, and anxiolytic properties. [3]
The Mayo Clinic Alix School of Medicine (MCASOM), formerly known as Mayo Medical School (MMS), [2] is a research-oriented medical school based in Rochester, Minnesota, with additional campuses in Arizona and Florida. [9] MCASOM is a school within the Mayo Clinic College of Medicine and Science (MCCMS), the education division of the Mayo Clinic ...
Clinical equipoise allows investigators to continue a trial until they have enough statistical evidence to convince other experts of the validity of their results, without a loss of ethical integrity on the part of the investigators. Equipoise is also an important consideration in the design of a trial from a patient’s perspective.
Resatorvid (TAK-242) is a cyclohexane derivative that was invented by scientists at Takeda in a drug discovery campaign to identify inhibitors of the receptor TLR4. [1] It binds directly to cysteine residue 747 [1] intracellularly, preventing TLR4 binding with TIRAP and thus preventing downstream signal transduction.