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Mycobacterium avium complex (MAC), also called Mycobacterium avium-intracellulare complex, is a microbial complex of three Mycobacterium species (i.e. M. avium, M. intracellulare, and M. chimaera). [6] It causes Mycobacterium avium-intracellulare infection. [7] [8] Some sources also include Mycobacterium avium subspecies paratuberculosis (MAP). [9]
These bacteria cause Mycobacterium avium-intracellulare infections or Mycobacterium avium complex infections in humans. [2] These bacteria are common and are found in fresh and salt water, in household dust and in soil. [3] MAC bacteria usually cause infection in those who are immunocompromised or those with severe lung disease.
MAC is used to compare the strengths, or potency, of anaesthetic vapours. [1] The concept of MAC was first introduced in 1965. [2] MAC actually is a median value, not a minimum as term implies. The original paper proposed MAC as the minimal alveolar concentration, [3] which was shortly thereafter revised to minimum alveolar concentration. [4]
Mycobacterium avium complex (MAC) is the most common cause of NTM lung disease in most countries, including the United States. [6] Classically, MAC infection results in either upper lobe cavities in male smokers with COPD or bronchiectasis in thin, older women; however, it is possible to have both cavities and bronchiectasis in the same patient ...
Mycobacterium avium complex (MAC) is a group of two bacteria, M. avium and M. intracellulare, that typically co-infect, leading to a lung infection called mycobacterium avium-intracellulare infection. [11] [12] Mycobacterium tuberculosis is a species of bacteria that causes tuberculosis, a respiratory infection. [13]
It also includes lung manifestations of autoimmune diseases such as Sjögren syndrome or rheumatoid arthritis. [ 3 ] [ 4 ] Histopathologic studies have shown that the tree-in-bud pattern is caused by demarcation of the normally invisible branching course of the peripheral airways, which usually results from bronchioles being plugged or blocked ...
The most common clinical manifestation of NTM disease is lung disease, but lymphatic, skin/soft tissue, and disseminated diseases are also important. [ 10 ] Pulmonary disease caused by NTM is most often seen in postmenopausal women and patients with underlying lung diseases such as cystic fibrosis , bronchiectasis , and prior tuberculosis .
Pneumono: from ancient Greek (πνεύμων, pneúmōn) which means lungs; ultra: from Latin, meaning beyond; micro and scopic: from ancient Greek, meaning small looking, referring to the fineness of particulates; silico-: from Latin, silicon; volcano: from Latin, referring to volcano; coni: from ancient Greek (κόνις, kónis) which means dust