Search results
Results From The WOW.Com Content Network
Friedel–Crafts alkylations can be reversible. Although this is usually undesirable it can be exploited; for instance by facilitating transalkylation reactions. [10] 1,3-Diisopropylbenzene is produced via transalkylation, a special form of Friedel–Crafts alkylation. It also allows alkyl chains to be added reversibly as protecting groups.
The photo-Fries rearrangement can likewise give [1,3] and [1,5] products, [7] [8] which involves a radical reaction mechanism. This reaction is also possible with deactivating substituents on the aromatic group.
Friedel–Crafts acylation; Friedel–Crafts alkylation; Friedländer synthesis; Fries rearrangement; Fritsch–Buttenberg–Wiechell rearrangement; Fujimoto–Belleau reaction; Fujiwara–Moritani reaction; Fukuyama coupling; Fukuyama indole synthesis; Fukuyama reduction
Via the Hock rearrangement, cyclohexylbenzene hydroperoxide cleaves to give phenol and cyclohexanone. Cyclohexanone is an important precursor to some nylons. [8] Starting with the alkylation of benzene with mixture of 1 and 2-butenes, the cumene process produces phenol and butanones. [5]
In organic chemistry, a rearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule. [1] Often a substituent moves from one atom to another atom in the same molecule, hence these reactions are usually intramolecular.
Clemmensen reduction conditions are particularly effective at reducing aryl [4]-alkyl ketones, [5] [6] such as those formed in a Friedel-Crafts acylation. The two-step sequence of Friedel-Crafts acylation followed by Clemmensen reduction constitutes a classical strategy for the primary alkylation of arenes.
For example, Friedel–Crafts acylation uses acetyl chloride (CH 3 COCl) as the agent and aluminum chloride (AlCl 3) as a catalyst to add an acetyl group to benzene: [2] Friedel-Crafts acylation of benzene by ethanoyl chloride. This reaction is an example of electrophilic aromatic substitution.
Fischer-Hepp rearrangement This organic reaction was first described by the German chemist Otto Philipp Fischer (1852–1932) and Eduard Hepp (June 11, 1851 – June 18, 1917) [ 3 ] in 1886, and is of importance because para - NO secondary anilines cannot be prepared in a direct reaction.