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The MCV can be conceptualized as the total volume of a group of cells divided by the number of cells. For a real world sized example, imagine you had 10 small jellybeans with a combined volume of 10 μL. The mean volume of a jellybean in this group would be 10 μL / 10 jellybeans = 1 μL / jellybean. A similar calculation works for MCV.
The normal mean corpuscular volume (abbreviated to MCV on full blood count results, and also known as mean cell volume) is approximately 80–100 fL. When the MCV is <80 fL, the red cells are described as microcytic and when >100 fL, macrocytic (the latter occurs in macrocytic anemia). The MCV is the average red blood cell size.
The Mentzer index, described in 1973 by William C. Mentzer, [1] is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. [2] [3] The index is calculated from the results of a complete blood count.
This parameter is, therefore, not influenced by the average RBC size (mean corpuscular volume, MCV). [7] RDW-CV (expressed in %) is calculated with the following formula: RDW-CV = (1 standard deviation of RBC volume ÷ MCV) × 100%. [8] Since RDW-CV is mathematically derived from MCV, it is therefore affected by the average RBC size (MCV). [7]
Mean corpuscular volume (MCV) is the average volume of a red blood cell and is calculated by dividing the hematocrit (Hct) by the concentration of red blood cell count. [citation needed] = [] Normal range: 80–100 fL (femtoliter)
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