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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Ceftriaxone, sold under the brand name Rocephin, is a third-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [4] These include middle ear infections, endocarditis, meningitis, pneumonia, bone and joint infections, intra-abdominal infections, skin infections, urinary tract infections, gonorrhea, and pelvic inflammatory disease. [4]
In pharmacokinetics, the rate of infusion (or dosing rate) refers not just to the rate at which a drug is administered, but the desired rate at which a drug should be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective. Abbreviations include K in, [1] K 0, [2] or R 0.
Ceftaroline fosamil / s ɛ f ˈ t ær oʊ l iː n /, brand name Teflaro in the US and Zinforo in Europe, [1] [2] is a cephalosporin antibiotic with anti-MRSA activity. [3] Ceftaroline fosamil is a prodrug of ceftaroline. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria.
An inhaled powdery particle that is >8 μm is structurally predisposed to depositing in the central and conducting airways (conducting zone) by inertial impaction. [47] An inhaled powdery particle that is between 3 and 8 μm in diameter tend to largely deposit in the transitional zones of the lung by sedimentation. [47]
In the dog, the half-life of cefovecin is 5.5 days, and in the cat, it is 6.9 days. [7] In birds and reptiles, the half-life is only a few hours, much shorter than in dogs and cats. [ 8 ] In cats, 99% of cefovecin is bound to proteins in the blood plasma .
The drug is administered intravenously every 6 or 8 hr, typically over 3–30 min. It may also be administered by continuous infusion over four hours. Prolonged infusions are thought to maximize the time that serum concentrations are above the minimum inhibitory concentration (MIC) of the bacteria implicated in infection.
The Expanded Program on Immunization (EPI) in the Philippines began in 1976 [1] through Presidential Decree No. 996 signed by President Ferdinand Marcos. [2] And, in 1986, made a response to the Universal Child Immunization goal. The four major strategies include: [3]