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Mohs surgery is the gold standard method for obtaining complete margin control during removal of a skin cancer (complete circumferential peripheral and deep margin assessment - CCPDMA) using frozen section histology. [1] CCPDMA or Mohs surgery allows for the removal of a skin cancer with very narrow surgical margin and a high cure rate.
For a small basal-cell cancer in a young person, the treatment with the best cure rate (Mohs surgery or CCPDMA) might be indicated. In the case of an elderly frail man with multiple complicating medical problems, a difficult to excise basal-cell cancer of the nose might warrant radiation therapy (slightly lower cure rate) or no treatment at all.
Preventive measures against cSCC include minimizing exposure to ultraviolet radiation and the use of sunscreen. [5] [6] Surgical removal is the typical treatment method, [2] employing simple excision for minor cases or Mohs surgery for more extensive instances. [2] Other options include cryotherapy and radiation therapy. [7]
Usually, recurrent tumors after radiation are treated with surgery, and not with radiation. Further radiation treatment will further damage normal tissue, and the tumor might be resistant to further radiation. Radiation therapy may be contraindicated for treatment of nevoid basal-cell carcinoma syndrome. A 2008 study reported that radiation ...
A meta-analysis of the literature in 2014 found no randomized controlled trials of surgical interventions to treat lentigo maligna or melanoma in-situ, even though surgery is the most widely used treatment. [144] Mohs surgery has been done with cure rate reported to be as low as 77%, [109] and as high as 95% by another author. [110]
Comparing Mohs Surgery Method to smashing an aluminum pie pan How a Mohs Section is flattened with relaxing incisions False negative in standard bread loafing histology: If the pathologist looks only at the margin of the three narrow slices, the many cancerous cells on the discarded margins will be missed.
SGc is commonly treated with wide local excision or Mohs micrographic surgery, and the relative survival rates at 5 and 10 years are 92.72 and 86.98%, respectively. [ 6 ] Epidemiology
The success rate of Mohs surgery is comparable to radiation therapy in squamous cell carcinoma, and one should also discuss this before approaching high-risk squamous cell cancers of the ear or lips. Combining these modalities should be considered to increase the cure rate in selective cases, and should also be discussed.