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A nociceptor (from Latin nocere 'to harm or hurt'; lit. ' pain receptor ' ) is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [ 1 ] [ 2 ] [ 3 ] to the spinal cord and the brain.
The somatosensory cortex decodes nociceptor info to determine the exact location of pain and is where proprioception is brought into consciousness; inferior cerebellar peduncle is all unconscious proprioception. Insula judges the intensity of the pain and provides the ability to imagine pain. [21] [22]
C fibers synapse to second-order projection neurons in the spinal cord at the upper laminae of the dorsal horn in the substantia gelatinosa. [5] The second-order projection neurons are of the wide dynamic range (WDR) type, which receive input from both nociceptive terminals as well as myelinated A-type fibers. [5]
External receptors that respond to stimuli from outside the body are called exteroreceptors. [4] Exteroreceptors include chemoreceptors such as olfactory receptors and taste receptors, photoreceptors (), thermoreceptors (temperature), nociceptors (), hair cells (hearing and balance), and a number of other different mechanoreceptors for touch and proprioception (stretch, distortion and stress).
The biggest barrier is getting NAD+ into the body because it’s such a large molecule, says Dr. Guarente. For that reason, straight up ingestible NAD+ (for example, in a supplement) will likely ...
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