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[1] [3] Other forms of statin associated muscle damage usually resolve after stopping the involved statin. [1] Mild joint pain and rash may be present. [3] In people affected by SAAM, the median duration of statin therapy was 38 months before the onset of muscular symptoms. [4]
Muscle pain and other symptoms often cause patients to stop taking a statin. [88] This is known as statin intolerance. A 2021 double-blind multiple crossover randomized controlled trial (RCT) in statin-intolerant patients found that adverse effects, including muscle pain, were similar between atorvastatin and placebo. [89]
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In patients taking higher statin doses, a similarly low increase in muscle pain and weakness was present (5%) with no clear evidence of a dose-response relationship. Duration of treatment with atorvastatin is unlikely to increase the risk of muscle-related side effects as most occur within the first year of treatment, after which the risk is ...
Cholesterol-lowering medications such as statins are recommended for both men and women with coronary artery disease. They can help reduce symptoms and prevent heart attacks and death.
Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting protein synthesis within the muscle. [6] Statin therapy tends to not show any histopathological differences, and thus a biopsy does not reveal too much about the damage. Often, the damage is found within the mitochondria.