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Once the compound entered pre-clinical development, process chemistry developed a cost-effective and scalable synthesis. [107] In atorvastatin's case, a key element of the overall synthesis was ensuring stereochemical purity in the final drug substance, and hence establishing the first stereocenter became a key aspect of the overall design.
Prescription drug list prices in the United States continually are among the highest in the world. [1] [2] The high cost of prescription drugs became a major topic of discussion in the 21st century, leading up to the American health care reform debate of 2009, and received renewed attention in 2015.
Contains extensive information on over-the-counter drugs and their responsible use, including specific guidance on several drug classes in question-and-answer format and information on common drug interactions. UK Medicines and Healthcare Products Regulatory Agency list of substances on general sales list Archived 2014-03-07 at the Wayback Machine
Records exist of over 250,000 people treated from 1998 to 2001 with the statin drugs atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. [100] The incidence of rhabdomyolysis was 0.44 per 10,000 patients treated with statins other than cerivastatin.
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Persons consuming more than 10 grams/day of calcium carbonate (4 grams of elemental calcium) are at risk of developing milk-alkali syndrome, [19] but the condition has been reported in at least one person consuming only 2.5 grams/day of calcium carbonate (1 gram of elemental calcium), an amount usually considered moderate and safe. [20]
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