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One of the principal causes of arterial stiffening with age is vascular calcification. Vascular calcification is the deposition of mineral in the form of calcium phosphate salts in the smooth muscle-rich medial layer of large arteries including the aorta. DNA damage, especially oxidative DNA damage, causes accelerated vascular calcification. [11]
Calcium metabolism is the movement and regulation of calcium ions (Ca 2+) in (via the gut) and out (via the gut and kidneys) of the body, and between body compartments: the blood plasma, the extracellular and intracellular fluids, and bone.
Disorders of calcium metabolism occur when the body has too little or too much calcium. The serum level of calcium is closely regulated within a fairly limited range in the human body. In a healthy physiology, extracellular calcium levels are maintained within a tight range through the actions of parathyroid hormone , vitamin D and the calcium ...
Metastatic calcinosis cutis is the consequence of calcium salts precipitating in normal tissue due to an underlying abnormality in the metabolism of phosphate and/or calcium. [2] Metastatic calcification can result from any systemic condition raising serum calcium and/or phosphate levels. Chronic renal failure is the most frequent underlying ...
Calcipotriene causes a rapid rise in calcium ion levels. [31] Calcium ion levels can remain high for weeks if untreated and lead to an array of medical issues. [ 31 ] There are also cases of hypercalcemia reported due to dogs ingesting rodenticides containing a chemical similar to calcipotriene found in psoriasis cream. [ 31 ]
It is the region of the prostate gland that grows throughout life and causes the disease of benign prostatic enlargement. [6] [7] Anterior fibro-muscular zone (or stroma) — This area, not always considered a zone, [4] is usually devoid of glandular components and composed only, as its name suggests, of muscle and fibrous tissue. [2]