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The human body and even its individual body fluids may be conceptually divided into various fluid compartments, which, although not literally anatomic compartments, do represent a real division in terms of how portions of the body's water, solutes, and suspended elements are segregated. The two main fluid compartments are the intracellular and ...
The extracellular fluid, in particular the interstitial fluid, constitutes the body's internal environment that bathes all of the cells in the body. The ECF composition is therefore crucial for their normal functions, and is maintained by a number of homeostatic mechanisms involving negative feedback .
The extracellular fluid compartment is further subdivided into the interstitial fluid and the intravascular fluid compartments. Body fluids, bodily fluids, or biofluids, sometimes body liquids, are liquids within the body of an organism. [1] In lean healthy adult men, the total body water is about 60% (60–67%) of the total body weight; it is ...
In a 72 kg (159 lb) body containing 40 litres of fluid, about 25 litres is intracellular, [9] which amounts to 62.5%. Jackson's texts states 70% of body fluid is intracellular. [10] Extracellular fluid (1/3 of body water) is fluid contained in areas outside of cells. For a 40-litre body, about 15 litres is extracellular, [9] which amounts to 37.5%.
[1] [2] The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. [2] The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs.
V ECF a = Extracellular fluid volume after fluid loss; n ECF a = Amount of substance in ECF after fluid loss; V ECF b = Extracellular fluid volume before fluid loss (approximately 20% of body weight, or by using inulin) Osm b = Body osmolarity before loss (almost equal to plasma osmolality of 275-299 milli-osmoles per kilogram [4])
The intracellular calcium level is kept relatively low with respect to the extracellular fluid, by an approximate magnitude of 12,000-fold. This gradient is maintained through various plasma membrane calcium pumps that utilize ATP for energy, as well as a sizable storage within intracellular compartments.
In medicine, intravascular volume status refers to the volume of blood in a patient's circulatory system, and is essentially the blood plasma component of the overall volume status of the body, which otherwise includes both intracellular fluid and extracellular fluid.