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The source for the data below is the OECD Health Statistics 2018, released by the OECD in June 2018 and updated on 8 November 2018. [1]The unit of measurement used by the OECD is defined daily dose (DDD), defined as "the assumed average maintenance dose per day for a drug used on its main indication in adults". [2]
The American Psychiatric Association 2000 Practice Guideline advises that where no response is achieved within the following six to eight weeks of treatment with an antidepressant, switch to an antidepressant in the same class, and then to a different class. A 2006 meta-analysis review found wide variation in the findings of prior studies: for ...
Population studies have consistently shown major depression to be about twice as common in women as in men, although it is not yet clear why this is so. [7] The relative increase in occurrence is related to pubertal development rather than chronological age, reaches adult ratios between the ages of 15 and 18, and appears associated with psychosocial more than hormonal factors.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Compared to the general adult male population, the prevalence of depression is higher amongst male farmers (5.3% versus 9.8%, respectively). [14] [57] Agriculture Health Study reports show that 3.0% of the sample population has taken medication for their depression, [58] compared to 13.2% in the general population. [59]
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 83 ] [ 85 ] [ 86 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 83 ]
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