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Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Remifentanil's short context-sensitive half-life makes it ideal for intense pain of short duration. As such, it has been used for analgesia in labor successfully; however, it is not as effective as epidural analgesia. [10] In combination with propofol, remifentanil is used for anesthesia of patients undergoing electroconvulsive therapy. [11]
To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
Cymbiotika Ultimate Pain Balm is the best pain relief cream for sensitive skin due to its powerful blend of natural ingredients and ability to provide fast and targeted relief for pain and discomfort.
Fospropofol (INN [3]), often used as the disodium salt (trade name Lusedra [4]) is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy .
A recent [when?] study showed that cisatracurium pretreatment effectively decreases the incidence and severity of pain induced by propofol general anaesthesia. [ 10 ] Another study showed that hiccups accompanied by vomiting, insomnia, shortness of breath can also be relieved by the nondepolarizing muscle relaxant, cisatracurium, during total ...
abdominal pain, nausea, vomiting, jaundice, and bloody urine Cyanogen Chloride Gas: colorless Odor: pungent, irritating Seconds to minutes Headache, weakness, eye, nose and throat irritation, nausea, vomiting, and gasping for air Hydrogen chloride Gas: colorless, yellowish, or white Odor: strong, irritating Seconds to minutes