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Hands, feet, armpits, groin, and the facial area are among the most active regions of perspiration due to the high number of sweat glands (eccrine glands in particular) in these areas. When excessive sweating is localized (e.g. palms, soles, face, underarms, scalp) it is referred to as primary hyperhidrosis or focal hyperhidrosis.
According to Henry Gray's estimates, the palm has around 370 sweat glands per cm 2; the back of the hand has 200 per cm 2; the forehead has 175 per cm 2; the breast, abdomen, and forearm have 155 per cm 2; and the back and legs have 60–80 per cm 2. [2] In the finger pads, sweat glands pores are somewhat irregularly spaced on the epidermal ridges.
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For palmoplantar hyperhidrosis, 20% aluminum chloride hexahydrate in absolute anhydrous ethyl alcohol () is the most effective topical treatment. [4] Other topical treatments such as potassium permanganate, tannic acid (2 to 5 percent solutions), resorcinol, boric acid, formaldehyde, methenamine, and glutaraldehyde have yielded less than desirable results.
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The amount of sweat glands varies across the human body, being highest in hand and foot regions (200–600 sweat glands per cm 2). [19] The response of the skin and muscle tissue to external and internal stimuli can cause the conductance to vary by several microsiemens .
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Perspiration, also known as sweat, is the fluid secreted by sweat glands in the skin of mammals. [ 1 ] Two types of sweat glands can be found in humans: eccrine glands and apocrine glands . [ 2 ]